Request PDF on ResearchGate | Aspergillose pulmonaire invasive | Introduction: Invasive pulmonary aspergillosis (IPA) is an important cause of morbidity and. Propos. – Le diagnostic d’aspergillose pulmonaire invasive chez le patient neutropénique est difficile. Le scanner, le lavage bronchoalvéolaire et l’histologie . Revue des Maladies Respiratoires – Vol. 30 – N° S1 – p. A – Aspergillose pulmonaire invasive compliquant les leucémies aiguës myéloblastiques.

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Le diagnostic d’aspergillose invasive reste difficile. Invasive aspergillosis is an opportunistic infection, with frequent uplmonaire involvment. High-risk children are allogenic bone marrow recipients, and those with hematological malignancies, aplastic anemia or chonic granulomatous disease.

Profound and prolonged neutropenia, and corticosteroid therapy are the most important predisposing factors. Building and demolition works represent the major environmental risk factor.

Aspergillose pulmonaire invasive compliquant les leucémies aiguës myéloblastiques – EM|consulte

The diagnosis of invasive aspergillosis remains difficult to establish. Clinical manifestations are non-specific. Early thoracic computed tomographic scan shows halo sign in most cases. Subsequently appears the air crescent sign.


Culture of the organism allows species identification. Aspergillus hyphae can be found at cytological examination, knvasive a biopsy specimen is usually required to affirm tissue damage.

A new classification of invasive fungal infections pulmonairr immunocompromised patients was recently proposed by experts from the European Organization for Research and Treatment of Cancer and from the Mycoses Study Group of the National Institute of Allergy and Infectious Diseases.

On the basis of host linked criteria, microbiological, clinical and radiological features, invasive aspergilllosis is classified as proven, probable or possible. These definitions should not be used to guide clinical practice in therapy, but they will improve the quality of epidemiological data, and help the comparison of clinical trial results.

Aspergillosis, Child, Immunocompromised host. Journal page Archives Contents list.

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